EDIS Document

Publication #PI-64

Pesticide Toxicity Profile: Ethylenebis (Dithiocarbamate) Pesticides1

Frederick M. Fishel2

This document provides a general overview of human toxicity, a listing of laboratory animal and wildlife toxicities, and a cross reference of chemical, common, and trade names of ethylenebis (dithiocarbamate) (EBDC) pesticides used as fungicides and registered for use in Florida.


As a chemical family, the EBDC pesticides are regarded as fungicides with a wide range of uses, including control of early and late blights of potatoes and tomatoes and many other diseases of vegetables, fruit, commercial sod, and field crops. They are also used as seed treatments. Nabam has biocide uses for control of slime-forming fungi and bacteria in industrial processing water systems and industrial lubricants. They have been on the market since the 1930s and 40s. Members of this chemical family that remain on the market in the United States include mancozeb, metiram, and nabam. Product formulations of mancozeb are dry flowables, flowables, wettable powders, and microencapsulated. Mancozeb is a coordination product of zinc ion and maneb. Metiram is sold as a dry flowable formulation with a relatively small number of crop sites approved for use in Florida.


These fungicides may cause irritation of the skin, respiratory tract, and eyes. Metiram is considered to have moderate acute toxicity. It is not significantly absorbed through the skin. Of the EBDC members, nabam shows the greatest toxicity, probably due to its greater water solubility and absorbability. Mancozeb is essentially water insoluble; therefore, skin absorption of this active ingredient is probably very limited. In 1987, the EPA conducted a special review of the EBDC compounds because of concerns about the potential health effects from dietary exposure to residues left on food crops and occupational exposure. It was concluded that the actual levels of EBDC residues on produce purchased by consumers are too low to affect human health. Many home garden uses of EBDCs have been cancelled because the EPA assumed that home users of these pesticides do not wear protective clothing during application. Systemic poisonings of humans have been extremely rare. No tests for these fungicides or their breakdown products in body fluids are available. Mammalian toxicities for the EBDC fungicides are shown in Table 1. Table 2 lists the toxicities to wildlife by the common name of the pesticide. Table 3 provides a cross listing of many of the trade names under which these products are registered and sold in Florida.

Additional Information

Nesheim, O.N., F.M. Fishel and M.A. Mossler. 2005. Toxicity of pesticides. PI-13. Gainesville: University of Florida Institute of Food and Agricultural Sciences. http://edis.ifas.ufl.edu/PI008.

Reigart, J.R. and J.R. Roberts. 2013. Recognition and management of pesticide poisonings, 6th ed. United States Environmental Protection Agency Publication EPA-735K-13001.

Seyler, L.A., et.al. 1994. Extension toxicology network (EXTOXNET). Cornell University and Michigan State University. http://extoxnet.orst.edu/index.html. Visited September 2005.


Table 1. 

EBDC fungicide mammalian toxicities (mg/kg of body weight).

Common name

Rat oral LD50

Rabbit dermal LD50






>2,000 (rat)




Table 2. 

EBDC fungicide wildlife toxicity ranges.

Common name

Bird acute oral LD50 (mg/kg)*

Fish (ppm)**














* Bird LD50: Practically nontoxic (PNT) = >2,000; slightly toxic (ST) = 501–2,000; moderately toxic (MT) = 51–500; highly toxic (HT) = 10–50; very highly toxic (VHT) = <10.

** Fish LC50: PNT = >100; ST = 10–100; MT = 1–10; HT = 0.1–1; VHT = <0.1.

† Bee: HT = highly toxic (applied product and residues kill upon contact); MT = moderately toxic (kills if applied over bees); PNT = relatively nontoxic (relatively few precautions necessary).

Table 3. 

Cross reference list of common, trade and chemical names of EBDC fungicides.

Common name

Trade names*

Chemical name


Bonide, Koverall, Mancozeb, Manzate, Rainshield®, Dithane®, Fore, Nubark, Penncozeb®, Pentathlon, Phoenix Wingman, Potato Seed Treater, Protect, Roper

Coordination product of zinc ion, manganese ethylenebis(dithiocarbamate)



Tris[ammine-[ethylene bis(dithiocarbamato)]zinc(II)[tetrahydro-1,2,4,7-dithiadiazocine-3,8-dithione] polymer


No products containing solely nabam are registered in FL

Disodium ethylenebis(dithiocarbamate)

* Does not include manufacturer's prepackaged mixtures.



This document is PI-64, one of a series of the Agronomy Department, UF/IFAS Extension. Original publication date September 2005. Revised September 2008, March 2014, and March 2017. Visit the EDIS website at http://edis.ifas.ufl.edu.


Frederick M. Fishel, professor, Agronomy Department, and director, Pesticide Information Office; UF/IFAS Extension, Gainesville, FL 32611.

The use of trade names in this publication is solely for the purpose of providing specific information. UF/IFAS does not guarantee or warranty the products named, and references to them in this publication does not signify our approval to the exclusion of other products of suitable composition. Use pesticides safely. Read and follow directions on the manufacturer's label.

The Institute of Food and Agricultural Sciences (IFAS) is an Equal Opportunity Institution authorized to provide research, educational information and other services only to individuals and institutions that function with non-discrimination with respect to race, creed, color, religion, age, disability, sex, sexual orientation, marital status, national origin, political opinions or affiliations. For more information on obtaining other UF/IFAS Extension publications, contact your county's UF/IFAS Extension office.

U.S. Department of Agriculture, UF/IFAS Extension Service, University of Florida, IFAS, Florida A & M University Cooperative Extension Program, and Boards of County Commissioners Cooperating. Nick T. Place, dean for UF/IFAS Extension.