September 2005

ToxTalk

  • wpdoc11.gifRick Relyea at the University of Pittsburgh has recently had published several journal articles that link the use of Roundup® to global amphibian decline (Arch. Environ. Contam. Toxicol. 48, 351-357, Eco. Appl. 15(4), 1118-1124). While the thought that one stressor is at fault for this phenomenon may be comforting to some, the conclusions of his ecological assessment are based on both incorrect assumptions and model selection. The author was able to generate some toxicity values slightly less than those known for Roundup® by testing the frogs for 16 days rather than the standard four days, with solution renewal every four days. The slightly lower-than-previous values should not have been unexpected since the exposure period was four times longer than normal. The use of renewal every four days also simulated retreatment at 4, 8, and 12 days after the initial treatment. Toxicologists have grappled with the ramifications of static versus static-renewal versus flow-through for some time. He also generated a value that would have placed the material in a “highly toxic” category, but this was with a predator in the same cage - a design that is not acceptable for pesticide toxicity testing, in addition to the length of the test. The author then uses the toxicity values for a deterministic ecological risk assessment of Roundup® applied to a one-foot pond with no overhead vegetation (using dispersion modeling). Not surprisingly, the author’s toxicity values were close to modeled concentration values - apparently supporting his underlying hypothesis. The flaw in the ecological assessment is that Roundup® is not used for aquatic sites and there would be no need for glyphosate at all if there wasn’t overhead vegetation. The author concedes that the component that is most lethal to amphibians in Roundup® is the surfactant, not the glyphosate. The EPA knew this based on the aforementioned values and so did the registrant. That is why when glyphosate is registered for use in aquatic sites (as Rodeo®), it is not formulated with a surfactant. The user must add a surfactant to it (and usually the surfactant is much less toxic than the one in Roundup®). This is a prime example of poor assessment design leading to apocalyptic predictions (at least for amphibians).
  • wpdoc12.gifThe EPA recently issued an experimental use permit (EUP) to Syngenta Seeds to test a B.t. line of corn in a number of states. The proposed issuance was put to public comment on November 5, 2003. Fourteen comments were received, all of which objected to the issuance. Commenters expressed concerns regarding human health, non-target organisms, genetic stability of the plant-incorporated protectant, invasive species, endangered species, B.t. protein in soil, insect resistance and management, impact of this EUP on the use of foliar B.t., impacts on organic crops and farmers, identity preservation, and several other topics. The EPA responded that “for organic products under NOP, the fact that some portion of the crop was pollinated by B.t. corn from a crop planted outside the boundaries of an appropriately segregated organic crop would not adversely impact the farmer’s ability to sell the crop as organic.” The Agency went on to state that it “has concluded that there is a reasonable certainty that no harm will result from dietary exposure to this protein as expressed in genetically modified corn.” The EUP was issued on August 10, 2005, and it was effective from May 6, 2004 until August, 15, 2005, leaving the company only five days to do the work.

Note: Keep in mind this is only using 2.9 g of toxin to protect 300 acres of corn - an amazingly small amount.

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